“The Trump administration has signaled that it may reconsider the Obama administration’s hands-off policy with respect to state laws legalizing recreational marijuana use, but not medicinal marijuana use. So the recent changes we have seen are unlikely to be entirely rolled back.

One of the principal reasons that the founders adopted a federalist system was to enable local resistance to unpopular federal policies. The recent success of the marijuana legalization movement suggests that, at least sometimes, the system continues to work as the founders intended.”

Source: Constitutional Connections: Marijuana regulation and federalism